Questions for Your Child's Doctor

Preparing for your first office visit

  • Is my child developing too quickly?
  • Do you think my child has central precocious puberty?
  • What causes central precocious puberty?
  • What are long-term issues to worry about with central precocious puberty?
  • What does sexual development have to do with a child's height?

Before diagnostic tests

  • What tests can you use to determine if my child has central precocious puberty?
  • Does my child need to have all these tests?
  • Which tests are the most important?
  • Will the tests be hard on my child?

After diagnostic tests

  • What are the results of my child’s bone scan?
  • Can you tell me about my child’s hormone levels?
  • Does my child require treatment for central precocious puberty?
  • What treatments are available for my child?
  • What are the advantages/disadvantages of these treatments?
  • Which treatment do you recommend? Why?
  • How can I help my child cope with having central precocious puberty?

About SUPPRELIN® LA

  • Does having the implant inserted under the skin hurt?
  • How long does the implantation procedure take?
  • Will my child feel the implant while it is in place?
  • Might the implant come out on its own?
  • How will my child feel while on SUPPRELIN LA?
  • What are the side effects related to SUPPRELIN LA?
  • How long will my child need the treatment?

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Indication

SUPPRELIN® LA (histrelin acetate) subcutaneous implant is used for the treatment of children with central precocious puberty (CPP).

Important Safety Information

  • SUPPRELIN LA should not be used by women who are or may become pregnant, and in patients who are allergic to gonadotropin releasing hormone (GnRH) or GnRH agonist analogs. Safety and effectiveness in children under 2 years of age has not been determined.

  • SUPPRELIN LA, like other GnRH agonists, may cause a temporary increase in the blood levels of specific hormones associated with the onset of puberty (estrogen in girls and testosterone in both sexes) during the first week of treatment. This increase may temporarily worsen puberty symptoms during the first week, additionally, you may see new symptoms appear during this period. Within the 4 weeks of treatment with SUPPRELIN LA, hormonal suppression generally occurs and the physical signs of puberty should decrease.

  • Your doctor should monitor the levels of specific hormones associated with puberty progression, 1 month after starting SUPPRELIN LA and then every 6 months thereafter. Every 6-12 months, height and bone age should be also monitored by your doctor.

  • During the clinical trial testing of SUPPRELIN LA, the most common side effects involved the implant site and included temporary bruising, pain, soreness, redness of the skin and swelling.

Please talk with your doctor for more information or if you have any questions.