Home|Prescribing Information|Contact Us|Site Map
Possible Side Effects

In the first few weeks of treatment, like all GnRH agonist medicines, SUPPRELIN® LA may cause a temporary increase in sex hormones. During this time, you may notice more signs of puberty in your child, including some vaginal bleeding and breast enlargement in girls. Within
4 weeks after treatment is started, you should see signs that puberty is stopping.

The most common side effects of SUPPRELIN LA are skin reactions where the implant has been placed. Such reactions may include bruising, soreness, pain, tingling, itching, and swelling. They usually go away within 2 weeks on their own. Call the doctor if your child has bleeding, redness, or pain at the implant site. These may not be all the side effects of SUPPRELIN LA. Ask your doctor for more information about side effects.

Register with SUPPRELIN LA

Indication

SUPPRELIN® LA (histrelin acetate) implant is used for the treatment of children with central precocious puberty (CPP).

Important Safety Information

SUPPRELIN LA should not be used by women who are or may become pregnant, and in patients who are allergic to gonadotropin releasing hormone (GnRH) or GnRH agonist analogs. Safety and effectiveness in children under 2 years of age has not been determined.

SUPPRELIN LA, like other GnRH agonists, may cause a temporary increase in the blood levels of specific hormones associated with the onset of puberty (estrogen in girls and testosterone in both sexes) during the first week of treatment. This increase may temporarily worsen puberty symptoms during the first week, additionally, you may see new symptoms appear during this period. Within the 4 weeks of treatment with SUPPRELIN LA, hormonal suppression generally occurs and the physical signs of puberty should decrease.

Your doctor should monitor the levels of specific hormones associated with puberty progression, 1 month after starting SUPPRELIN LA and then every 6 months thereafter. Every 6-12 months, height and bone age should be also monitored by your doctor.

During the clinical trial testing of SUPPRELIN LA, the most common side effects involved the implant site and included temporary bruising, pain, soreness, redness of the skin and swelling.

Please talk with your doctor for more information or if you have any questions.

Endo Pharmaceuticals
Rx Only
© 2010 Endo Pharmaceuticals. All rights reserved.
SUPPRELIN® LA is a registered trademark of Endo Pharmaceuticals.
SP-1007/June 2009

Privacy/Legal
Intended for U.S. Residents Only