Full Prescribing Information|Medication Guide

The SUPPRELIN® LA (histrelin acetate) SHARES Copay Assistance Program

Don’t let a copay stand in your way

The majority of patients enrolled in the SUPPRELIN® LA SHARES Copay Assistance Program pay $0 out of pocket for the SUPPRELIN® LA implant.

Contact the SUPPRELIN® LA Support Center at 855-270-0123 for details on your coverage and how to save up to $10,000 on each implant.

Restrictions may apply. See terms and conditions.*

Support Center Contact Info

Offer good only in the USA and void where prohibited or otherwise restricted by law. Offer not valid for prescriptions that may be reimbursed under a federal or state healthcare program, including Medicare, Medicaid, or any other federal or state healthcare programs, including any state medical pharmaceutical assistance programs. Patients over the age of 18 are not eligible. Endo has the right to rescind, revoke, or amend this program without notice. A confirmed diagnosis consistent with ICD-10-CM Diagnosis Code E22.8 is required to participate in this program. This offer is not transferable. Patient, pharmacist, and prescriber agree not to seek reimbursement for all or any part of the benefit received by the patient through this offer. Patient is responsible for reporting receipt of this coupon benefit to any insurer, health plan, or other third party who pays for or reimburses any part of the prescription filled using the coupon, as may be required.

Order an all-in-one Caregiver Kit for information about SUPPRELIN® LA and CPP
Download important information about CPP and how SUPPRELIN® LA can help
 
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IMPORTANT SAFETY INFORMATION ABOUT SUPPRELIN® LA

  • SUPPRELIN LA should not be taken if your child is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or any ingredients in the SUPPRELIN LA implant, or is pregnant or becomes pregnant. SUPPRELIN LA can cause birth defects or loss of the baby. If your child becomes pregnant, call your doctor.

  • In the first week of treatment, SUPPRELIN LA can cause an increase in some hormones. During this time, you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping.

  • Some people have had implant breakage during the removal process.

  • Some people who had SUPPRELIN LA placed in their arm have had the implant come through the skin (extrusion). Call your child's doctor right away if the SUPPRELIN LA implant comes through the skin.

  • Some people taking GnRH agonists like SUPPRELIN LA have had new or worsening mental (psychiatric) problems including depression. Mental (psychiatric) problems may include emotional symptoms such as crying, irritability, restlessness (impatience), anger, and acting aggressive. Before your child receives SUPPRELIN LA, tell the doctor if they have a history of mental problems. Call your child's doctor right away if your child has any new or worsening mental symptoms or problems while taking SUPPRELIN LA.

  • Some people taking GnRH agonists like SUPPRELIN LA have had seizures. The risk of seizures may be higher in people who have a history of seizures, epilepsy, brain or brain vessel (cerebrovascular) problems or tumors, or who are taking a medicine that has been connected to seizures such as bupropion or selective serotonin reuptake inhibitors (SSRIs). Seizures have also happened in people who have not had any of these problems. Before your child receives SUPPRELIN LA, tell the doctor if they have a history of these problems, as well as all the medicines they take. Call your child's doctor right away if your child has a seizure while taking SUPPRELIN LA.

  • Severe cutaneous (skin) adverse reactions can happen during treatment with GnRH agonists like SUPPRELIN LA. Stop SUPPRELIN LA and call your child's doctor right away if your child has any of the following signs or symptoms during treatment with SUPPRELIN LA: skin rash or acne, blisters or sores in the mouth, dry skin, peeling of the skin, itching, fever, blisters on the skin, muscle or joint aches, redness or swelling of the face, hands, or soles of the feet, and/or swollen glands.

  • Increased pressure in the fluid around the brain can happen in children taking GnRH agonist medicines, including SUPPRELIN LA. Call your child's doctor right away if your child has any of the following symptoms during treatment with SUPPRELIN LA: headache, eye problems, including blurred vision, double vision, and decreased eyesight, eye pain, ringing in the ears, dizziness, nausea.

  • Your child's doctor should do tests to make sure your child has CPP before treating with SUPPRELIN LA. SUPPRELIN LA lasts for 12 months. One implant will give the medicine for 12 months. After 12 months, SUPPRELIN LA must be removed. The doctor may insert a new SUPPRELIN LA at this time to continue treatment.

  • SUPPRELIN LA is placed under the skin of the inside of the upper arm. The doctor will numb the arm of your child, make a small cut, and then place SUPPRELIN LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage.

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours after receiving the SUPPRELIN LA implant. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in a few days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions.

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. Sometimes the doctor will have to do special tests, such as ultrasound or MRI, if the SUPPRELIN LA implant is difficult to find under your child's skin.

  • The most common side effects of SUPPRELIN LA are skin reactions at the place where the implant is inserted. These reactions may include pain, redness, bruising, soreness, and swelling in and around the implant site. Call your child's doctor if your child has bleeding, redness, or severe pain where the implant was inserted.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

WHAT IS SUPPRELIN® LA?

  • SUPPRELIN LA is an implanted gonadotropin releasing hormone (GnRH) medicine used for the treatment of children with central precocious puberty (CPP).

  • It is not known if SUPPRELIN LA is safe and effective in children under 2 years of age.

Click for full Prescribing Information, including Medication Guide.

See More
IMPORTANT SAFETY INFORMATION ABOUT SUPPRELIN® LA

  • SUPPRELIN LA should not be taken if your child is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or any ingredients in the SUPPRELIN LA implant, or is pregnant or becomes pregnant. SUPPRELIN LA can cause birth defects or loss of the baby. If your child becomes pregnant, call your doctor.

  • In the first week of treatment, SUPPRELIN LA can cause an increase in some hormones. During this time, you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping.

  • Some people have had implant breakage during the removal process.

  • Some people who had SUPPRELIN LA placed in their arm have had the implant come through the skin (extrusion). Call your child's doctor right away if the SUPPRELIN LA implant comes through the skin.

  • Some people taking GnRH agonists like SUPPRELIN LA have had new or worsening mental (psychiatric) problems including depression. Mental (psychiatric) problems may include emotional symptoms such as crying, irritability, restlessness (impatience), anger, and acting aggressive. Before your child receives SUPPRELIN LA, tell the doctor if they have a history of mental problems. Call your child's doctor right away if your child has any new or worsening mental symptoms or problems while taking SUPPRELIN LA.

  • Some people taking GnRH agonists like SUPPRELIN LA have had seizures. The risk of seizures may be higher in people who have a history of seizures, epilepsy, brain or brain vessel (cerebrovascular) problems or tumors, or who are taking a medicine that has been connected to seizures such as bupropion or selective serotonin reuptake inhibitors (SSRIs). Seizures have also happened in people who have not had any of these problems. Before your child receives SUPPRELIN LA, tell the doctor if they have a history of these problems, as well as all the medicines they take. Call your child's doctor right away if your child has a seizure while taking SUPPRELIN LA.

  • Severe cutaneous (skin) adverse reactions can happen during treatment with GnRH agonists like SUPPRELIN LA. Stop SUPPRELIN LA and call your child's doctor right away if your child has any of the following signs or symptoms during treatment with SUPPRELIN LA: skin rash or acne, blisters or sores in the mouth, dry skin, peeling of the skin, itching, fever, blisters on the skin, muscle or joint aches, redness or swelling of the face, hands, or soles of the feet, and/or swollen glands.

  • Increased pressure in the fluid around the brain can happen in children taking GnRH agonist medicines, including SUPPRELIN LA. Call your child's doctor right away if your child has any of the following symptoms during treatment with SUPPRELIN LA: headache, eye problems, including blurred vision, double vision, and decreased eyesight, eye pain, ringing in the ears, dizziness, nausea.

  • Your child's doctor should do tests to make sure your child has CPP before treating with SUPPRELIN LA. SUPPRELIN LA lasts for 12 months. One implant will give the medicine for 12 months. After 12 months, SUPPRELIN LA must be removed. The doctor may insert a new SUPPRELIN LA at this time to continue treatment.

  • SUPPRELIN LA is placed under the skin of the inside of the upper arm. The doctor will numb the arm of your child, make a small cut, and then place SUPPRELIN LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage.

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours after receiving the SUPPRELIN LA implant. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in a few days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions.

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. Sometimes the doctor will have to do special tests, such as ultrasound or MRI, if the SUPPRELIN LA implant is difficult to find under your child's skin.

  • The most common side effects of SUPPRELIN LA are skin reactions at the place where the implant is inserted. These reactions may include pain, redness, bruising, soreness, and swelling in and around the implant site. Call your child's doctor if your child has bleeding, redness, or severe pain where the implant was inserted.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

WHAT IS SUPPRELIN® LA?

  • SUPPRELIN LA is an implanted gonadotropin releasing hormone (GnRH) medicine used for the treatment of children with central precocious puberty (CPP).

  • It is not known if SUPPRELIN LA is safe and effective in children under 2 years of age.

Click for full Prescribing Information, including Medication Guide.

References: 1. SUPPRELIN® LA [package insert]. Endo Pharmaceuticals Inc. 2. Eugster EA, Clarke W, Kletter GB, et al. Efficacy and safety of histrelin subdermal implant in children with central precocious puberty: a multicenter trial. J Clin Endocrinol Metab. 2007;92(5):1697-1704. 3. Silverman LA, Neely EK, Kletter GB, et al. Long-term continuous suppression with once-yearly histrelin subcutaneous implants for the treatment of central precocious puberty: a final report of a phase 3 multicenter trial. J Clin Endocrinol Metab. 2015;100(6):2354-2363. 4. Data on file. DOF-SP-27. Endo Pharmaceuticals Inc.; August 2020.

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